OneThera
OneThera Zero Irritation Skincare Line
OneThera. One Goal. Zero irritation.

Every formula achieved an Irritation Index of 0.00 in clinical skin irritation testing.

Powered by pharmacist-developed 3-Code formulations designed to minimize irritation while supporting healthier-looking skin and visible results.

3-Code Precision Skincare System Clinically Tested Irritation Index 0.00 Developed by Pharmacist Founders HPR 0.1% Next-Generation Retinoid
Explore Formulations View Clinical Data
Scroll
About OneThera Brand
About Brand

Built by a pharmacist. For skin that gave up on retinol.
Products Visual
Products

3-Code Precision Skincare System
Clinical Proof
Clinical Proof

Irritation Index 0.00
Founder Portrait
Partnership

Buyer Information

About Brand

Pharmacy Frontlines Consultation
Pharmacist-Led Brand Philosophy

약국에서 반복되던 고민이 포뮬러가되었습니다.

월 15,000명 이상이 방문하는 약국에서 같은 질문이 반복되었습니다. “레티놀은 효과가 좋다는데, 자극이 무서워 시작하지 못하겠어요.” 원인은 레티놀 자체가 아니라 피부 안의 전환 과정에 있었습니다. 원쎄라는 그 전환 과정을 생략한 HPR 성분에 주목했습니다. 그것이 브랜드의 시작이었습니다.

  • Formulated by licensed pharmacists
  • Operate multiple top-rated pharmacies in Korea on Google Reviews
  • More than 15,000 monthly pharmacy visitors
Market Opportunity

북미 레티놀 시장의 공백을 겨냥했습니다.

0.0%

U.S. K-Beauty CAGR (2026~2033)

0%

Retinol Routine Discontinuation Rate

0%

Dermocosmetic Transparency Demand

0.0%

U.S. Retinol CAGR (2025~2030)

Market Gap

강한 자극의 레티놀과 체감이 약한 진정 제품 사이. 그 사이에서 루틴을 이어가지 못하는 소비자가 존재합니다. 원쎄라는 그 공백을 성분 메커니즘 수준에서 해결했습니다.

Repurchase Structure

매일 사용할 수 없는 제품은 루틴이 되기 어렵습니다. 루틴이 없으면 재구매도 없습니다. Irritation Index 0.00의 포뮬러는 매일 밤 이어지는 루틴을 가능하게 합니다.

What is your skin concern?

Select a skin concern and we'll recommend the optimal solution.

A-1 Retino Rejuvenating Serum

Product Code A-1 Detail Image

600 x 600 px (product-a1-serum.png)

Code A-1

RETINO REJUVENATING SERUM (30 ml / 1.01 fl. oz.)

HPR 0.1% & PDRN 2,000ppm Turn-over Boosting Serum

HPR 0.1%, PDRN 2,000ppm, Niacinamide, Centella Asiatica Extract, Camellia Seed Oil.

Irritation Index 0.00

Unlike traditional retinol that requires conversion, HPR 0.1% acts directly to bypass irritation pathways. Enhanced with PDRN 2,000ppm, it intensively treats scars and rough textures. Centella and Camellia seed oil offer rich soothing.

  • [Turnover Support] Maximized skin turnover care with next-gen HPR active
  • [Targeted Healing] Spot boosting for scars with concentrated PDRN
A-2 PDRN Rejuvenating Cream

Product Code A-2 Detail Image

600 x 600 px (product-a2-cream.png)

Code A-2

PDRN REJUVENATING CREAM (30 ml / 1.01 fl. oz.)

PDRN 2,000ppm & Tranexamic Acid 3% Barrier Defense Cream

PDRN 2,000ppm, Tranexamic Acid 3%, Niacinamide 2%, Centella Asiatica Extract, Ceramide.

Irritation Index 0.00

Fuses Tranexamic Acid 3% for non-irritating brightening and Ceramide to build a robust defense shield. Minimizes skin damage while locking in absolute nourishment.

  • [Pigment Block] Prevents spots and dullness with Tranexamic Acid 3%
  • [Barrier Shield] Ceramide formulation defends skin from external irritants
B-1 Hydra Glow Hyaluronic Serum

Product Code B-1 Detail Image

600 x 600 px (product-b1-serum.png)

Code B-1 Clinical Trial In Progress

HYDRA GLOW HYALURONIC SERUM (50 ml / 1.69 fl. oz.)

Multi-weight Hyaluronic Glow Boosting Serum

Various molecular weights of hyaluronic acid reach deep dry skin layers to resolve inner tightness.

Absorbs instantly without stickiness to relieve inner dryness and sensitivity, promoting a clear, dewy skin radiance.

  • [Layered Hydration] Resolves dehydration instantly via multi-depth hydration
B-2 Hydra Barrier Beta-Glucan Cream

Product Code B-2 Detail Image

600 x 600 px (product-b2-cream.png)

Code B-2 Clinical Trial In Progress

HYDRA BARRIER BETA-GLUCAN CREAM (50 ml / 1.69 fl. oz.)

Beta-Glucan Moisture Shielding & Comfort Cream

Beta-glucan coating shield to lock in hydration and prevent water loss.

A non-sticky, high-performing moisture barrier that shields sensitised skins from environmental stressors.

  • [Moisture Shielding] Completely blocks water loss even under harsh dry climates
C-1 Core Volume Lifting Cream
Coming Soon
Code C-1 Clinical Trial In Progress

OneThera PDLLA Cream 30ml (30 ml / 1.01 fl. oz.)

PDLLA 100,000ppm Core Volume Lifting Cream

Powered by PDLLA 100,000ppm, the next-generation collagen supporter.

High-concentration formula of aesthetic-grade PDLLA structurally lifts collapsed contours and rebuilds core skin density.

  • [Structural Density] Restores facial volume and improves contour definition
D-1 D-Day One PDRN Mask Pack
Coming Soon
Code D-1 Clinical Trial In Progress

D-DAY ONE PDRN MASK PACK (Total 25 ml / 0.84 fl. oz.)

The next-generation recovery solution by OneThera

Coming soon.

The next-generation recovery solution by OneThera. Coming soon.

Before & After

피부 변화로 확인하는 원쎄라의 기준

임상 비포애프터 자료는 제공되는 이미지 기준으로 정리하며, 추후 자료가 추가되면 순차 업데이트됩니다.

좌우로 드래그하여 비교하세요

Rejuvenating Line wrinkle before
Rejuvenating Line wrinkle after
BEFORE 사용 전 (0주) AFTER 사용 2주 후

리쥬비네이팅 라인 / PDRN 크림 · 레티노 세럼

Glabella Wrinkle Improvement

피부결, 자극감, 컨디션 변화를 중심으로 확인한 임상 이미지입니다. (미간 주름 개선)

Rejuvenating Line redness before
Rejuvenating Line redness after
BEFORE 물리적 자극 후 AFTER 제품 1회 사용 후

리쥬비네이팅 라인 / PDRN 크림 · 레티노 세럼

Irritation Soothing & Barrier Support

피부결, 자극감, 컨디션 변화를 중심으로 확인한 임상 이미지입니다. (외부 자극 진정 및 붉은기 진정)

Rejuvenating Line spots before
Rejuvenating Line spots after
BEFORE 사용 전 (0주) AFTER 사용 2주 후

리쥬비네이팅 라인 / PDRN 크림 · 레티노 세럼

Pigmentation & Spot Improvement

피부결, 자극감, 컨디션 변화를 중심으로 확인한 임상 이미지입니다. (기미 및 색소침착 개선)

Clinically Proven

Independent dermatology lab testing completed. 30 subjects, 4-week repeated patch test results.

SKIN IRRITATION INDEX
1.80

Clinically Classified as Non-Irritant

Tested by ProbeM Skin Research Center under strict dermatological control

ProbeM Clinical Certificate 1

ProbeM Certificate 1

image_0cc007.jpg

Click to Enlarge

Skin Irritation Test Certificate (Code A-1 Serum)

Institute: ProbeM Skin Research Center | Result: Non-irritant (0.00)

ProbeM Clinical Certificate 2

ProbeM Certificate 2

image_0cc022.jpg

Click to Enlarge

Skin Irritation Test Certificate (Code A-2 Cream)

Institute: ProbeM Skin Research Center | Result: Non-irritant (0.00)

※ This clinical study was conducted by ProbeM Skin Research Center, an independent dermatology research institute, in compliance with MFDS guidelines.

Clinical Efficacy FAQ

Conducted by ProbeM Skin Research Center following MFDS guidelines. A 24-hour closed patch test was performed on 30 subjects with sensitive skin. Skin irritation scores were evaluated 24 and 48 hours after patch removal, yielding a mean score of 0.00 (Non-Irritant).
Traditional retinol must be converted first into Retinaldehyde and then Retinoic Acid in the skin, which commonly triggers inflammation, peeling, and dryness. OneThera HPR 0.1% uses a next-generation retinoic acid ester that binds directly to skin retinoid receptors without conversion, delivering anti-aging efficacy with zero irritation risk.
Yes, OneThera formulas are built under the strict guidelines of the US FDA Modernization of Cosmetics Regulation Act (MoCRA). Ingredients lists are fully transparent, fragrance-free, free of 20 high-alert allergens, and prepared for US cosmetic facility and product listing compliance.

Her Purchase. Her Impact. Her Community. Her Legacy.

Healthy restoration for the self. Meaningful impact for the world.

01

Authentic Ritual Sharing

Community members voluntarily share product experiences and brand philosophy through short-form content and daily routines.

02

Care-Drop Giving Program

Purchases generated through individual community codes help support donations of essential care products to underserved women.

03

Transparent Impact Tracking

A live donation tracker on the official store shares real-time community contribution results transparently.

04

Value-Driven Community Building

More than a beauty customer base, One:Sisters is designed as a community built around conscious consumption and positive social impact.

Coming Soon

Donation data will be available once sales begin.

Live Donation Tracker

$0

Goal: $10,000
0 Donations
0 Beneficiaries
0 Campaigns
One:Sisters Campaign Ritual
One:Sisters Campaign Lab Research
One:Sisters Campaign Giving Care

OneThera believes skincare should go beyond surface-level beauty. Through the One:Sisters campaign, we support women in underserved communities by providing essential care items and creating a more sustainable culture of giving. Just as our formulas are designed to restore what skin has lost, we aim to help fill overlooked gaps in everyday dignity and care. OneThera is committed to growing as a high-end beauty house built on both performance and responsibility.

[Sustainability] Clean formulations developed with respect for both skin and environment [Social Impact] Supporting essential care access for women in underserved communities

For modern premium consumers, value-driven purchasing has become part of the luxury experience. OneThera's social impact philosophy creates deeper emotional loyalty beyond product performance alone. We welcome partners who want to grow alongside this long-term movement.

Buyer Information

When former retinol users return to the category, One-Thera deserves consideration.

OneThera Model Skincare Shot

Why One-Thera

  • • [Market White Space Opportunity] As global consumers grow fatigued by low-cost, all-in-one K-beauty formulas, One-Thera introduces a more advanced alternative: pharmacist-developed precision skincare system through the 3-Code system.
  • • [Designed for Repeat Use] High-performance actives including PDRN and PDLLA are formulated at optimized concentrations. Positive user experiences may help encourage continued use and routine consistency.
  • • [Safety Without Compromise] Developed under the strict standards of a pharmacist-led R&D team. Potential claim and irritation risks are carefully considered during formulation development to support long-term retail confidence.
  • • [Clinical Testing Support] Transparent clinical testing data supports stronger and more credible marketing execution for retail and distribution partners.

Target Consumer Profile

  • [The Result-Seeker] A performance-driven consumer seeking high-function dermocosmetic solutions with visible, efficient results rather than complicated skincare routines.
  • [The Ingredient-Savvy] A premium consumer familiar with high-performance actives such as PDRN and retinoids, balancing aesthetic treatments with advanced homecare routines.
  • [The Sensitive Skin] A consumer who values ingredient purity over trend-driven marketing and trusts pharmacist-developed clean beauty rooted in minimal, non-irritating formulation philosophy.
OneThera Serum Texture Close-up
OneThera Studio Product Line

Compliance Checklist

  • FDA MoCRA Compliant
  • 20 Toxins Free
  • Dermatologically Tested (0.00)
  • CGMP Certified Facility
  • Health Canada CNF Registered
OneThera Global Brand Ambassador Group

Bring One-Thera's precision skincare codes to your market. Our brand partnership team will respond within 24 hours.

Samples are available for immediate shipment. Ingredient sheets and brand decks are prepared. Launch timeline discussions are available.

Regulatory Status for Selected Region:

Ingredient Mechanism

자극 경로는 줄이고, 효과는 남겼습니다.

Bypassing Irritation Pathways Directly

일반 레티놀은 피부 안에서 여러 단계를 거쳐 활성화됩니다. 자극은 그 과정에서 발생합니다. HPR(Hydroxypinacolone Retinoate) 0.1%는 전환 과정 없이 직접 작용합니다. 자극이 발생하는 경로 자체를 설계 단계에서 줄였습니다.

Retinol vs HPR Conversion Pathway

Traditional Retinol:
Retinol → Retinal → Retinoic Acid (Active)
※ Causes skin peeling, redness, and sensitivity.
OneThera HPR Retinoid:
HPR 0.1% (Direct Active) → Binds Receptors Directly
Bypasses conversion for 0.00 irritation index.
Quality & Regulatory Readiness

북미 더마코스메틱 시장의 리스크를 관리했습니다.

북미 시장의 리스크는 크게 세 가지입니다. 불명확한 성분 함량, 자극 유발 성분, 그리고 과장된 클레임. 원쎄라는 이를 설계 단계에서부터 관리했습니다. 전 성분과 함량을 투명하게 공개하고 향료와 색소를 배제했습니다. 생산 단계별 안정성 테스트를 완료하고 MoCRA 컴플라이언스 기준을 통과했습니다.

Clean formula. Compliant claims. Stable supply.
Pharmacist-developed formula
Full concentration transparency
No fragrance or artificial colors
Sensitive skin compatibility
Stability testing completed
MoCRA compliance ready

OneThera, Gaining Global Attention

Recognized by global beauty editors and ingredient-conscious consumers.

"The meeting of PDRN and retinoid — an extraordinary experience of skin density filling without any irritation." - Global Beauty Editor

PARTNERSHIP

Ready to Launch, Ready to Support

Samples, ingredient sheets, and brand materials are prepared for immediate partnership discussions.

CONTACT

Jennie Kim

Marketing Manager

chaeeun0726@re-han.com